[CAS NO. 136468-36-5] Foropafant

Name: Foropafant
Brand: Arctom Scientific
SKU: AS075140

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PRODUCTS SPECIFICATIONS [136468-36-5]

Distributor

Catalog

AS075140

Brand

Arctom Scientific

CAS

136468-36-5

DESCRIPTION [136468-36-5]

Overview

MDL	MFCD00904759
Molecular Weight	464.72
Molecular Formula	C28H40N4S
SMILES	CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC2=CC=CN=C2)C(=C1)C(C)C

For research use only. We do not sell to patients.

Summary

Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor ( PAF ) receptor, with a K _i value of 57 pM for [ ³ H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets ^[1] .

IC50 & Target

Ki: 57 pM ([ ³ H]PAF binding) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 215.18 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1518 mL	10.7592 mL	21.5183 mL
5 mM	0.4304 mL	2.1518 mL	4.3037 mL
10 mM	0.2152 mL	1.0759 mL	2.1518 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.38 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.