[CAS NO. 1391934-91-0] MAT2Ainhibitor4

Name: MAT2Ainhibitor4
Brand: Arctom Scientific
SKU: AS937893

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PRODUCTS SPECIFICATIONS [1391934-91-0]

Distributor

Catalog

AS937893

Brand

Arctom Scientific

CAS

1391934-91-0

DESCRIPTION [1391934-91-0]

Overview

MDL	-
Molecular Weight	275.75
Molecular Formula	C16H15ClFN
SMILES	CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1

For research use only. We do not sell to patients.

Summary

MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2 ( MAT2A ). MAT2A inhibitor 4 can be used for the research of cancer ^[1] .

IC50 & Target

MAT2A ^[1]

In Vitro

MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 906.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6265 mL	18.1324 mL	36.2647 mL
5 mM	0.7253 mL	3.6265 mL	7.2529 mL
10 mM	0.3626 mL	1.8132 mL	3.6265 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.54 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Sviripa VM, et al. 2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2. J Med Chem. 2014;57(14):6083-6091.