[CAS NO. 1394238-91-5] Fmoc-Val-Ala-PAB-OH
PRODUCTS SPECIFICATIONS [1394238-91-5]
DESCRIPTION [1394238-91-5]
Overview
| MDL | MFCD28557282 |
|---|---|
| Molecular Weight | 515.60 |
| Molecular Formula | C30H33N3O5 |
| SMILES | OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O |
Summary
Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] .
IC50 & Target
|
Protease Cleavable |
Cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 33.33 mg/mL ( 64.64 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL |
| 5 mM | 0.3879 mL | 1.9395 mL | 3.8790 mL |
| 10 mM | 0.1939 mL | 0.9697 mL | 1.9395 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 0.56 mg/mL (1.09 mM); Clear solution
