[CAS NO. 139893-43-9] Simvastatinacidammonium

Name: Simvastatinacidammonium
Brand: Arctom Scientific
SKU: AS904450

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PRODUCTS SPECIFICATIONS [139893-43-9]

Distributor

Catalog

AS904450

Brand

Arctom Scientific

CAS

139893-43-9

DESCRIPTION [139893-43-9]

Overview

MDL	MFCD07773041
Molecular Weight	453.61
Molecular Formula	C25H43NO6
SMILES	O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+]

For research use only. We do not sell to patients.

Summary

Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene ^[1] ^[2] .

IC50 & Target

HMG-CoA reductase, Reactive oxygen species ^[1] ^[2]

In Vitro

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells ^[2] .
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[2]

Cell Line:	hCM and HEK293 (transfected with OATP3A1)
Concentration:	0.1, 1, 10 and 20 μM
Incubation Time:	24 h
Result:	Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 11.11 mg/mL ( 24.49 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2045 mL	11.0227 mL	22.0454 mL
5 mM	0.4409 mL	2.2045 mL	4.4091 mL
10 mM	0.2205 mL	1.1023 mL	2.2045 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-

1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-

1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, (βR,δR,1S,2S,6R,8S,8aR)-

Simvastatin acid ammonium salt

Simvastatin ammonium salt

Simvastatin carboxylic acid ammonium salt

Ammonium simvastatin