[CAS NO. 1421227-52-2] WS3
PRODUCTS SPECIFICATIONS [1421227-52-2]
DESCRIPTION [1421227-52-2]
Overview
| MDL | MFCD26142950 |
|---|---|
| Molecular Weight | 569.58 |
| Molecular Formula | C28H30F3N7O3 |
| SMILES | O=C(C1CC1)NC2=NC=NC(OC3=CC=C(NC(NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3)=C2 |
Summary
WS3 is a novel proliferative molecule that promotes pancreatic
β cell proliferation
in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes
[1]
.
IC50 & Target
IC50: 0.28 μM (β cell proliferation) [1]
In Vitro
WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC
50
value of 0.28 μM
[1]
.
WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 2.2 mg/mL ( 3.86 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7557 mL | 8.7784 mL | 17.5568 mL |
| 5 mM | --- | --- | --- |
| 10 mM | --- | --- | --- |
-
1.
Add each solvent one by one: 50% PEG300 >> 50% saline
Solubility: 3.33 mg/mL (5.85 mM); Suspended solution; Need ultrasonic
References
- [1] Shen W, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72.
- [2] Jonathan G Swoboda, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
