[CAS NO. 1425973-14-3] NH2-PEG7

Name: NH2-PEG7
Brand: Arctom Scientific
SKU: AS012004

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PRODUCTS SPECIFICATIONS [1425973-14-3]

Distributor

Catalog

AS012004

Brand

Arctom Scientific

CAS

1425973-14-3

DESCRIPTION [1425973-14-3]

Overview

MDL	MFCD28385479
Molecular Weight	325.40
Molecular Formula	C14H31NO7
SMILES	OCCOCCOCCOCCOCCOCCOCCN

For research use only. We do not sell to patients.

Summary

NH2-PEG7 is a PROTAC linker , which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6 ^[1] .

IC50 & Target

PEGs

Appearance

Solid-liquid mixture

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 307.31 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0731 mL	15.3657 mL	30.7314 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.