[CAS NO. 1430056-54-4] AKT-IN-6

Name: AKT-IN-6
Brand: Arctom Scientific
SKU: AS949601

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1430056-54-4]

Fulfillment

Catalog

AS949601

Brand

Arctom Scientific

CAS

1430056-54-4

DESCRIPTION [1430056-54-4]

Overview

MDL	MFCD30470660
Molecular Weight	389.43
Molecular Formula	C22H20FN5O
SMILES	N#CC1=C(C2=CC3=C(C(N([C@@H](CC4=CC=CC(F)=C4)CN)C3)=O)C=C2)N(C)N=C1

For research use only. We do not sell to patients.

Summary

AKT-IN-6 (Example 13) is a potent Akt inhibitor . AKT-IN-6 inhibits Akt1 , Akt2 and Akt3 with IC ₅₀ s < 500nM, respectively. (patent WO2013056015A1).

IC50 & Target

Akt1

Akt2

Akt3

In Vitro

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 320.98 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5679 mL	12.8393 mL	25.6786 mL
5 mM	0.5136 mL	2.5679 mL	5.1357 mL
10 mM	0.2568 mL	1.2839 mL	2.5679 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

* All of the co-solvents are available by MCE.