[CAS NO. 1435934-25-0]  A419259trihydrochloride

A 419259 Trihydrochloride is a second-generation pyrrolo-pyrimidine designed to enhance selectivity towards the Src family relative to other cytoplasmic tyrosine kinases. A-419259 inhibits K-562 cells with an IC ₅₀ between 0.1 and 0.3 μM, and Meg-01 proliferation with an IC ₅₀ of approximately 0.1 μM. A-419259 also potently induces apoptosis in K-562 cells beginning at 0.1 μM and increasing in a dose-dependent manner. PP2 inhibits Src kinase autophosphorylation in both Ph ⁺ cell lines (K-562 and Meg-01) with an IC ₅₀ between 3 and 10 μM, while A-419259 blocks kinase activation between 0.1 and 0.3 μM. A-419259 strongly inhibits DAGM/Bcr-Abl cell proliferation in the absence of IL-3 with an IC ₅₀ between 0.1 and 0.3 μM ^[1] . A-419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, and blocks proliferation and induces apoptosis in CML cell lines. A-419259 inhibits overall SFK activity in K562 and other CML cell lines with an IC ₅₀ value of 0.1-0.3 μM ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.