[CAS NO. 1448188-57-5] VL285

Name: VL285
Brand: Arctom Scientific
SKU: HY-111663

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PRODUCTS SPECIFICATIONS [1448188-57-5]

Distributor

Catalog

HY-111663

Brand

MCE

CAS

1448188-57-5

MDL	-
Molecular Weight	532.65
Molecular Formula	C29H32N4O4S
SMILES	CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2

For research use only. We do not sell to patients.

VL285 is a potent VHL ligand with an IC ₅₀ of 0.34 μM ^[1] .

VHL

Treatment with VL285 attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 100 mg/mL ( 187.74 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

* All of the co-solvents are available by MCE.