[CAS NO. 145733-36-4] Tasosartan

Name: Tasosartan
Brand: Arctom Scientific
SKU: AS503551

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PRODUCTS SPECIFICATIONS [145733-36-4]

Fulfillment

Catalog

AS503551

Brand

Arctom Scientific

CAS

145733-36-4

DESCRIPTION [145733-36-4]

Overview

MDL	MFCD00865905
Molecular Weight	411.46
Molecular Formula	C23H21N7O
SMILES	O=C1CCC2=C(C)N=C(C)N=C2N1CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3

For research use only. We do not sell to patients.

Summary

Tasosartan is a long-acting angiotensin II ( AngII ) receptor antagonist.

IC50 & Target

Angiotensin II (AngII) receptor ^[1]

In Vitro

Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro. IC ₅₀ for inhibition of specific binding of ¹²⁵ I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 303.80 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4304 mL	12.1518 mL	24.3037 mL
5 mM	0.4861 mL	2.4304 mL	4.8607 mL
10 mM	0.2430 mL	1.2152 mL	2.4304 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-

Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-

5,8-Dihydro-2,4-dimethyl-8-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(6H)-one

WAY-ANA 756

Tasosartan

Verdia

2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one