[CAS NO. 1458576-00-5] Biotin-PEG4-alkyne

Name: Biotin-PEG4-alkyne
Brand: Arctom Scientific
SKU: AS867588

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PRODUCTS SPECIFICATIONS [1458576-00-5]

Fulfillment

Catalog

AS867588

Brand

Arctom Scientific

CAS

1458576-00-5

DESCRIPTION [1458576-00-5]

Overview

MDL	-
Molecular Weight	457.58
Molecular Formula	C21H35N3O6S
SMILES	O=C(NCCOCCOCCOCCOCC#C)CCCC[C@H]1SC[C@@]([C@@]1([H])N2)([H])NC2=O

For research use only. We do not sell to patients.

Summary

Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 218.54 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1854 mL	10.9271 mL	21.8541 mL
5 mM	0.4371 mL	2.1854 mL	4.3708 mL
10 mM	0.2185 mL	1.0927 mL	2.1854 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.