[CAS NO. 146662-42-2] SR2640 hydrochloride
PRODUCTS SPECIFICATIONS [146662-42-2]
DESCRIPTION [146662-42-2]
Overview
| MDL | MFCD04971976 |
|---|---|
| Molecular Weight | 406.86 |
| Molecular Formula | C23H19ClN2O3 |
| SMILES | OC(C(C=CC=C1)=C1NC2=CC(OCC3=NC4=CC=CC=C4C=C3)=CC=C2)=O.[H]Cl |
Summary
SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma [1] .
IC50 & Target
LTD4 and LTE4 [1]
In Vivo
SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC
50
of 3 nM
[1]
.
SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Guinea pigs (injected with LTD4 and LTE4) [1] |
| Dosage: | 1 mg/kg |
| Administration: | IV; single dosage |
| Result: | Specifically prevented the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL ( 614.46 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4578 mL | 12.2892 mL | 24.5785 mL |
| 5 mM | 0.4916 mL | 2.4578 mL | 4.9157 mL |
| 10 mM | 0.2458 mL | 1.2289 mL | 2.4578 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution
