[CAS NO. 14782-19-5] INO5042
PRODUCTS SPECIFICATIONS [14782-19-5]
DESCRIPTION [14782-19-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 281.29 |
| Molecular Formula | C15H7NO3S |
| SMILES | O=C(C1=C2SC(C3=CC=CO3)=N1)C4=C(C=CC=C4)C2=O |
Summary
In Vitro
When INO5042 is added to endothelial cells, a shift of velocities is observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results is significantly found when neutrophils, alone or along with endothelium, has been submitted to INO5042, the number of stickers and rollers being reduced as well [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 2 mg/mL ( 7.11 mM ; ultrasonic and adjust pH to 3 with HCl)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5550 mL | 17.7752 mL | 35.5505 mL |
| 5 mM | 0.7110 mL | 3.5550 mL | 7.1101 mL |
| 10 mM | --- | --- | --- |
References
- [1] Renard M, et al. Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells. Biorheology. 2003;40(1-3):173-8.
- [2] Fosse C, et, al. Parameters and mechanistic studies on the oxidative ring cleavage of synthetic heterocyclic naphthoquinones by Streptomyces strains. Appl Microbiol Biotechnol. 2004 Sep;65(4):446-56.
