[CAS NO. 1480833-70-2] PF-04885614

Name: PF-04885614
Brand: Arctom Scientific
SKU: AS127818

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PRODUCTS SPECIFICATIONS [1480833-70-2]

Distributor

Catalog

AS127818

Brand

Arctom Scientific

CAS

1480833-70-2

DESCRIPTION [1480833-70-2]

Overview

MDL	-
Molecular Weight	285.26
Molecular Formula	C13H14F3N3O
SMILES	NC(C)(C)C1=NC=C(C2=CC=C(OC(F)(F)F)C=C2)N1

For research use only. We do not sell to patients.

Summary

PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 876.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5056 mL	17.5279 mL	35.0557 mL
5 mM	0.7011 mL	3.5056 mL	7.0111 mL
10 mM	0.3506 mL	1.7528 mL	3.5056 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Brady MAHER, et al. Treatment of Neurological and Neurodevelopmental Diseases and Disorders Associated with Aberrant Ion Channel Expression and Activity. US20180328915A1.