[CAS NO. 149719-06-2] RS 23597-190
PRODUCTS SPECIFICATIONS [149719-06-2]
DESCRIPTION [149719-06-2]
Overview
| MDL | MFCD00672672 |
|---|---|
| Molecular Weight | 363.28 |
| Molecular Formula | C16H24Cl2N2O3 |
| SMILES | O=C(OCCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.Cl |
Summary
IC50 & Target
|
5-HT 4 Receptor |
In Vitro
RS 23597-190 (10 µM; 4 days) significantly inhibits superoxide production in high glucose (30 mM) in 661W cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RS 23597-190 (6.0 mg/kg; i.v.) inhibits 5-HT-induced tachycardia in micropig [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Bilaterally vagotomized micropig [1] |
| Dosage: | 6.0 mg/kg |
| Administration: | I.v. |
| Result: | Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26.
- [2] Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204.
