[CAS NO. 1515855-97-6] JJKK 048
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PRODUCTS SPECIFICATIONS [1515855-97-6]
Fulfillment
Catalog
AS907421
Brand
Arctom Scientific
CAS
1515855-97-6
DESCRIPTION [1515855-97-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 434.44 |
| Molecular Formula | C23H22N4O5 |
| SMILES | O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)C4=CC=C(OCO5)C5=C4)CC1)N6N=CN=C6 |
For research use only. We do not sell to patients.
Summary
JJKK 048 is an ultrapotent and highly selective inhibitor of Monoacylglycerol lipase ( MAGL ).
IC50 & Target
MAGL [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
In Vitro:
DMSO : 33.33 mg/mL ( 76.72 mM ; ultrasonic and warming and heat to 60°C)
Preparing
Stock Solutions
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3018 mL | 11.5091 mL | 23.0181 mL |
| 5 mM | 0.4604 mL | 2.3018 mL | 4.6036 mL |
| 10 mM | 0.2302 mL | 1.1509 mL | 2.3018 mL |
*
Please refer to the solubility information to select the appropriate solvent.
In Vivo:
*
All of the co-solvents are available by MCE.
References
- [1] Aaltonen N, et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). J Pharmacol Exp Ther. 2016 Oct;359(1):62-72.
- [2] Aaltonen N, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90.
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