[CAS NO. 153808-85-6] Cadrofloxacin

Name: Cadrofloxacin
Brand: Arctom Scientific
SKU: AS136083

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PRODUCTS SPECIFICATIONS [153808-85-6]

Distributor

Catalog

AS136083

Brand

Arctom Scientific

CAS

153808-85-6

DESCRIPTION [153808-85-6]

Overview

MDL	-
Molecular Weight	411.38
Molecular Formula	C19H20F3N3O4
SMILES	O=C(O)C1=CN(C2=C(C1=O)C=C(C(N3C[C@@H](NCC3)C)=C2OC(F)F)F)C4CC4

For research use only. We do not sell to patients.

Summary

Cadrofloxacin (Caderofloxacin; CS-940), a orally active fluoroquinolone, is effective against aerobic/anaerobic Gram-positive and Gram-negative bacteria . Cadrofloxacin can be used for the research of infectious diseases ^[1] ^[2] ^[3] .

In Vitro

Cadrofloxacin against M.tuberculosis with a MIC ₅₀ of 0.25 μg/mL ^[1] .
Cadrofloxacin against Acinetobacter spp. and Stenotrophomonas (Xanthomonas) maltophilia with MIC ₉₀ s of 0.03 and 2 μg/ml, respectively ^[2] .
Cadrofloxacin against Haemophilus influenzae , Moraxella catarrhalis , and Neisseria spp. with MIC ₉₀ s less than or equal to 0.06 μg/mL ^[2] .
Cadrofloxacin against members of the family Enterobacteriaceae with MIC ₉₀ s of 0.015 to 16 μg/mL (median MIC ₉₀ , 0.06 μg/mL) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cadrofloxacin (9 mg/kg; i.g.; once or twice daily for 14 consecutive days) increases the activity of hepatic CYP2E1 in rats ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 180-220 g ^[2]
Dosage:	9 mg/kg
Administration:	I.g. once or twice daily for 14 consecutive days
Result:	Enhanced the expression of hepatic CYP2E1 mRNA, inducing a 1.6-fold increase compared with that of control rats. The level of CYP2E1 protein in the hepatic microsomes was significantly higher than control group, 190% of that in control rats.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 24.31 mM ; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4308 mL	12.1542 mL	24.3084 mL
5 mM	0.4862 mL	2.4308 mL	4.8617 mL
10 mM	0.2431 mL	1.2154 mL	2.4308 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (2.43 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (2.43 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (2.43 mM); Clear solution

* All of the co-solvents are available by MCE.