[CAS NO. 15489-90-4] Hematin
PRODUCTS SPECIFICATIONS [15489-90-4]
DESCRIPTION [15489-90-4]
Overview
| MDL | MFCD00011615 |
|---|---|
| Molecular Weight | 633.49 |
| Molecular Formula | C34H33FeN4O5 |
| SMILES | CC1=C(CCC(O)=O)C([N-]C1=CC(C(C)=C2C=C)=NC2=CC3=C4C)=CC(C(CCC(O)=O)=C5C)=NC5=CC([N-]3)=C4C=C.[Fe+3].[OH-] |
Summary
In Vitro
Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin
[2]
.
Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml
[2]
.
Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)
[2]
.
Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g) [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 1.43 mg/mL ( 2.26 mM ; ultrasonic and warming and heat to 70°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5786 mL | 7.8928 mL | 15.7856 mL |
| 5 mM | --- | --- | --- |
| 10 mM | --- | --- | --- |
References
- [1] Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57.
- [2] Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369.
- [3] Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43.
- [4] Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238.
- [5] Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4.
Synonyms
