[CAS NO. 15662-33-6] Ryanodine
PRODUCTS SPECIFICATIONS [15662-33-6]
DESCRIPTION [15662-33-6]
Overview
| MDL | MFCD00151119 |
|---|---|
| Molecular Weight | 493.55 |
| Molecular Formula | C25H35NO9 |
| SMILES | O[C@@]1([C@@]([C@@]2(O)O3)4C)[C@@]35[C@](O)(CC[C@H](C)[C@H]5O)[C@@](C2)(C)[C@@]1([C@H](OC(C6=CC=CN6)=O)[C@]4(O)C(C)C)O |
4 Publications Citing Use of MCE
Summary
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa .
IC50 & Target
Ryanodine receptor [1]
In Vivo
Ryanodine (100-5000 nM, 30-120 mintutes) irreversibly depresses twitch and tetanic tension of both fast and slow muscle in a dose-related manner [1] .
At concentrations above 250 nM, ryanodine induces a slowly developing, dose dependent contracture which could not be blocked by 5 mMCo 2+ [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03590522 | Assiut University |
Heart Failure
|
January 17, 2019 |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
Synonyms
