[CAS NO. 157922-77-5] Duocarmycin TM
PRODUCTS SPECIFICATIONS [157922-77-5]
DESCRIPTION [157922-77-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 466.91 |
| Molecular Formula | C25H23ClN2O5 |
| SMILES | ClC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1 |
1 Publications Citing Use of MCE
Summary
Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic . Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
IC50 & Target
|
Duocarmycins |
In Vitro
Duocarmycin TM (60 μM; 4 d; BJAB and WSU-DLCL2 cells) is a cytotoxic agent that inhibits the proliferation of tumor cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | BJAB and WSU-DLCL2 cells |
| Concentration: | 60 μM |
| Incubation Time: | 4 days |
| Result: | Inhibited the proliferation of tumor cells with IC 50 values of 0.153 μM and 0.079μM for BJAB and WSU-DLCL2 cells, respectively. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 107.09 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1417 mL | 10.7087 mL | 21.4174 mL |
| 5 mM | 0.4283 mL | 2.1417 mL | 4.2835 mL |
| 10 mM | 0.2142 mL | 1.0709 mL | 2.1417 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution
