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[CAS NO. 1600515-49-8] Tilfrinib
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-110244 |
| Brand: | MCE |
| CAS: | 1600515-49-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 275.30 |
| Molecular Formula | C17H13N3O |
| SMILES | OC1=CC=CC(NC2=C3C4=CC=CC=C4NC3=NC=C2)=C1 |
Summary
In Vitro
Tilfrinib (20 µM; 36 h) shows inhibition of PTK6, and decreases the ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs
[1]
.
Tilfrinib (compound 4f) shows good anti-proliferative activity against MCF7, HS-578/T and BT-549 cells with GI
50
values of 0.99, 1.02 and 1.58 µM
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | UM-UC-3 cells (stably expressing FLAG-ETV4 WT or Y392F) |
| Concentration: | 20 µM |
| Incubation Time: | 36 h |
| Result: | Reduced ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs by inhibiting PTK6. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 454.05 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6324 mL | 18.1620 mL | 36.3240 mL |
| 5 mM | 0.7265 mL | 3.6324 mL | 7.2648 mL |
| 10 mM | 0.3632 mL | 1.8162 mL | 3.6324 mL |
References
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