[CAS NO. 160807-49-8] Indirubin-3'-monoxime

Name: Indirubin-3'-monoxime
Brand: Arctom Scientific
SKU: AS904908

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PRODUCTS SPECIFICATIONS [160807-49-8]

Distributor

Catalog

AS904908

Brand

Arctom Scientific

CAS

160807-49-8

DESCRIPTION [160807-49-8]

Overview

MDL	MFCD02683594
Molecular Weight	277.28
Molecular Formula	C16H11N3O2
SMILES	O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C\3=N/O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.6065 mL	18.0323 mL	36.0646 mL
5 mM	0.7213 mL	3.6065 mL	7.2129 mL
10 mM	0.3606 mL	1.8032 mL	3.6065 mL
50 mM	0.0721 mL	0.3606 mL	0.7213 mL

Description

Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for , , , , ,respectively. Indirubin-3'-monoxime is a direct and selective inhibitor with IC50 of 7.8-10 µM.

Targets

CDK5-P35 ^[1] (Cell-free assay)	CDK1-cyclinB ^[1] (Cell-free assay)	CDK2-cyclinE ^[1] (Cell-free assay)	CDK2-cyclinA ^[1] (Cell-free assay)	CDK4-cyclinD1 ^[1] (Cell-free assay)
0.065 μM	0.18 μM	0.25 μM	0.44 μM	3.33 μM

References

[1] Hoessel R,et al. Nat Cell Biol. 1999 ;1(1):60-7.
[2] Blazevic T,et al. Cardiovasc Res. 2014 1;101(3):522-32.