[CAS NO. 1613404-76-4] Deltarasinhydrochloride
PRODUCTS SPECIFICATIONS [1613404-76-4]
DESCRIPTION [1613404-76-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 640.22 |
| Molecular Formula | C40H38ClN5O |
| SMILES | [H]Cl.C1(C2=CC=C(OC[C@@H](N3C4=CC=CC=C4N=C3C5=CC=CC=C5)C6CCNCC6)C=C2)=NC7=CC=CC=C7N1CC8=CC=CC=C8 |
2 Publications Citing Use of MCE
Summary
Deltarasin hydrochloride is an inhibitor of KRAS-PDEδ interaction with K d of 38 nM for binding to purified PDEδ.
IC50 & Target
Kd: 38 nM (PDEδ)
In Vitro
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with K D of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 52 mg/mL ( 81.22 mM )
H 2 O : 50 mg/mL ( 78.10 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5620 mL | 7.8098 mL | 15.6196 mL |
| 5 mM | 0.3124 mL | 1.5620 mL | 3.1239 mL |
| 10 mM | 0.1562 mL | 0.7810 mL | 1.5620 mL |
