[CAS NO. 1633009-87-6] BI 689648
PRODUCTS SPECIFICATIONS [1633009-87-6]
DESCRIPTION [1633009-87-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 298.34 |
| Molecular Formula | C16H18N4O2 |
| SMILES | O=C(N1CCCC2=C1N=CC(C3=CC(COC)=CN=C3)=C2)N |
Summary
BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC 50 s of 310 and 2.1 nM, respectively.
IC50 & Target
IC50: 310 nM (CYP11B1), 2.1 nM (CYP11B2) [1]
In Vitro
Compare with the FADs and LCI699, BI 689648 is highly selective in vitro , providing an IC 50 for CYP11B2 of 2.1 nM and a selectivity factor of 149 over CYP11B1. FAD286, by comparison, shows a similar IC 50 for CYP11B2 (2.5 nM); however, its greater potency against CYP11B1 (94 nM) results in a comparatively modest selectivity factor of 38, approximately 4-fold less than BI 689648 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of ~500 nM. For BI 689648 (aldosterone EC 50 =2 nM), appreciable changes in 11-DOC are only noted at plasma concentrations >2000 nM or >1000-fold its aldosterone EC 50 while FAD286 shows a window of ~100-fold. BI 689648 exhibits minimal impact on 11-DC and only at very high plasma concentrations (~10 μM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 30 mg/mL ( 100.56 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3519 mL | 16.7594 mL | 33.5188 mL |
| 5 mM | 0.6704 mL | 3.3519 mL | 6.7038 mL |
| 10 mM | 0.3352 mL | 1.6759 mL | 3.3519 mL |
