[CAS NO. 1636881-61-2] Mavoglurantracemate
PRODUCTS SPECIFICATIONS [1636881-61-2]
DESCRIPTION [1636881-61-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 313.39 |
| Molecular Formula | C19H23NO3 |
| SMILES | O=C(N1CC[C@@]2([H])[C@@](C#CC3=CC=CC(C)=C3)(O)CCC[C@@]12[H])OC |
Summary
Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist [1] .
In Vitro
For antagonistic activity, (−)-mavoglurant, the (−)-enantiomer shows IC 50 of 0.11 μM and 0.03 μM (Ca 2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 159.55 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1909 mL | 15.9546 mL | 31.9091 mL |
| 5 mM | 0.6382 mL | 3.1909 mL | 6.3818 mL |
| 10 mM | 0.3191 mL | 1.5955 mL | 3.1909 mL |
