[CAS NO. 163768-50-1] AuristatinF
PRODUCTS SPECIFICATIONS [163768-50-1]
DESCRIPTION [163768-50-1]
Overview
| MDL | MFCD25976745 |
|---|---|
| Molecular Weight | 745.99 |
| Molecular Formula | C40H67N5O8 |
| SMILES | CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)OC)C)=O)C(C)C)=O |
Summary
Auristatin F is a potent cytotoxin in antibo-conjugated drugs and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation. Auristatin F can be used in antibody-drug conjugates (ADC) [1] [2] .
IC50 & Target
Microtubule [1]
In Vitro
Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has C max of 8276.76 ng/mL. The AUC last is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats [2] | |||||||||||
| Dosage: | 5 mg/kg | |||||||||||
| Administration: | Intravenous injection | |||||||||||
| Result: |
|
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years |
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 200 mg/mL ( 268.10 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3405 mL | 6.7025 mL | 13.4050 mL |
| 5 mM | 0.2681 mL | 1.3405 mL | 2.6810 mL |
| 10 mM | 0.1341 mL | 0.6703 mL | 1.3405 mL |
References
- [1] Roy S, et al. SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chem Commun (Camb). 2017 Apr 11;53(30):4234-4237.
- [2] Park MH, et, al. Pharmacokinetic and Metabolism Studies of Monomethyl Auristatin F via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. Molecules. 2019 Jul 29;24(15):2754.
