[CAS NO. 163847-77-6] TAPI-1

Name: TAPI-1
Brand: Arctom Scientific
SKU: AS155758

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [163847-77-6]

Distributor

Catalog

AS155758

Brand

Arctom Scientific

CAS

163847-77-6

DESCRIPTION [163847-77-6]

Overview

MDL	MFCD02684280
Molecular Weight	499.60
Molecular Formula	C26H37N5O5
SMILES	O=C(N[C@@H](CC1=CC=C2C=CC=CC2=C1)C(N[C@@H](C)C(NCCN)=O)=O)[C@H](CC(C)C)CC(NO)=O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

TAPI-1 is a TACE ( ADAM17 ) inhibitor and blocks the shedding of several cell surface proteins ^[1] . TAPI-1 is also a metalloproteinase ( MMP ) inhibitor ^[2] .

IC50 & Target

TACE (ADAM17) ^[1] , MMP ^[2]

In Vitro

TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells ^[1] .
TAPI-1 attenuates oxidative stress and inflammatory cytokines ^[1]
LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	LPS-treated HK-2 cells
Concentration:	1 µM
Incubation Time:	30 minutes (pre-treated)
Result:	Increased cell viability.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL ( 62.05 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0016 mL	10.0080 mL	20.0160 mL
5 mM	0.4003 mL	2.0016 mL	4.0032 mL
10 mM	0.2002 mL	1.0008 mL	2.0016 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-

L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-, (R)-

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide

TAPI 1

TNF-a protease inhibitor 1