[CAS NO. 164650-44-6] Efinaconazole

Name: Efinaconazole
Brand: Arctom Scientific
SKU: AS034495

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [164650-44-6]

Fulfillment

Catalog

AS034495

Brand

Arctom Scientific

CAS

164650-44-6

DESCRIPTION [164650-44-6]

Overview

MDL	MFCD00936407
Molecular Weight	348.39
Molecular Formula	C18H22F2N4O
SMILES	[C@@]([C@@H](C)N1CCC(=C)CC1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8703 mL	14.3517 mL	28.7035 mL
5 mM	0.5741 mL	2.8703 mL	5.7407 mL
10 mM	0.2870 mL	1.4352 mL	2.8703 mL
50 mM	0.0574 mL	0.2870 mL	0.5741 mL

Description

Efinaconazole (KP-103) is an inhibitor of which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes.

Targets

14 alpha-demethylase ^[1]

In vitro

In in vitro antifungal susceptibility tests, efinaconazole shows lower minimum inhibitory concentration (MIC) than terbinafine, ciclopirox, itraconazole and amorolfine.

In vivo

Efinaconazole is a topical antifungal, so it has relatively low systemic accumulation. The plasma half-life after 10 days of administration is 29.9 h. It has high plasma protein-binding affinity from 95.8 to 96.5%; primarily to albumin, a1-acid glycoprotein and γ-globulin. Efinaconazole is metabolized extensively through oxidative and reductive processes resulting in a sole H3 metabolite. It may also undergo glucuronidation. Efinaconazole does not have significant interactions with CYP450 enzymes in the liver. CYP2C8, CYP2C9, CYP2C19 and CYP3A4 are inhibited by efinaconazole at concentrations higher than the systemic concentrations achieved clinically.

References

[1] Gupta AK, et al. Expert Rev Anti Infect Ther. 2014, 12(7):743-52.

Synonyms

1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-

1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,R*)]-

(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol

KP 103 (pharmaceutical)

KP 103

Efinaconazole

Jublia

(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(4H-1,3,4-triazol-4-yl)butan-2-ol