[CAS NO. 1673560-66-1] PD-1-IN-17

Name: PD-1-IN-17
Brand: Arctom Scientific
SKU: AS893232

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PRODUCTS SPECIFICATIONS [1673560-66-1]

Distributor

Catalog

AS893232

Brand

Arctom Scientific

CAS

1673560-66-1

DESCRIPTION [1673560-66-1]

Overview

MDL	MFCD30738000
Molecular Weight	374.35
Molecular Formula	C13H22N6O7
SMILES	OC[C@@H](C(O)=O)NC(N[C@H](C1=NN=C([C@@H](N)[C@H](O)C)O1)CCC(N)=O)=O

For research use only. We do not sell to patients.

Summary

PD-1-IN-17 is a programmed cell death-1 ( PD-1 ) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM ^[1] .

IC50 & Target

PD-1 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 333.91 mM ; Need ultrasonic)

H ₂ O : ≥ 100 mg/mL ( 267.13 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6713 mL	13.3565 mL	26.7130 mL
5 mM	0.5343 mL	2.6713 mL	5.3426 mL
10 mM	0.2671 mL	1.3356 mL	2.6713 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Pottayil Govindan Nair Sasikumar, et al. 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators. WO2015033301A1.