[CAS NO. 1684-40-8] Tacrine HCl

Name: Tacrine HCl
Brand: Arctom Scientific
SKU: AS030220

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PRODUCTS SPECIFICATIONS [1684-40-8]

Distributor

Catalog

AS030220

Brand

Arctom Scientific

CAS

1684-40-8

DESCRIPTION [1684-40-8]

Overview

MDL	MFCD00012657
Molecular Weight	234.72
Molecular Formula	C13H14N2.HCl
SMILES	NC1=C2C(=NC=3C1=CC=CC3)CCCC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.2604 mL	21.3020 mL	42.6040 mL
5 mM	0.8521 mL	4.2604 mL	8.5208 mL
10 mM	0.4260 mL	2.1302 mL	4.2604 mL
50 mM	0.0852 mL	0.4260 mL	0.8521 mL

Description

Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.

Targets

BChE ^[6] (Cell-free assay)	AChE ^[6] (Cell-free assay)
25.6 nM	31 nM

In vitro

Tacrine hydrochloride is an inhibitor of three different hepatic microsomal cytochrome P-450 enzyme sub-families. Tacrine hydrochloride at 40 mg/mL, 80 mg/mL or 200 mg/mL inhibits 3-hydroxymethyl antipyrine (HMA) production by 17%, 24% and 41% and OHA production by 52%, 55% and 79%, respectively, in hepatic microsome. Tacrine severely inhibits normal levels of secretion of soluble APP derivatives by cells into conditioned media in glial, fibroblast, pheochromocytoma (PC12), and neuroblastoma cells. Tacrine treatment does not alter the level of HSP-70 in cell extracts and tacrine affected mildly the secretion of PN-1 in neuroblastoma and PC12 cells. Tacrine (1 μM) attenuates the neurotoxic effect of A beta(25-35) in rat PC12 cells.

References

[1] Danbury TC, et al. Eur J Drug Metab Pharmacokinet, 1999, 24(1), 91-96.
[2] Lahiri DK, et al. J Neurosci Res, 1994, 37(6), 777-787.
[3] Svensson AL, et al. Neuroreport, 1998, 9(7), 1519-1522.
[4] Pavone F, et al. Behav Brain Res, 1997, 89(1-2), 229-236.
[5] Kim YK, et al. J Ethnopharmacol, 2003, 87(2-3), 149-154.
[6] Mushtaq Ahmed, et al. Chem Biol Interact . 2006 Aug 25;162(2):165-71.

Synonyms

9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1)

Acridine, 9-amino-1,2,3,4-tetrahydro-, monohydrochloride

9-Acridinamine, 1,2,3,4-tetrahydro-, monohydrochloride

Acridine, 9-amino-1,2,3,4-tetrahydro-, hydrochloride

Hydroaminacrine

Tacrin hydrochloride

Romotal

Tenakrin

THA

Tacrine hydrochloride

1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride

CI 970

Cognex

9-Amino-1,2,3,4-Tetrahydroacridine hydrochloride

5,6,7,8-Tetrahydroacridin-9-amine hydrochloride