[CAS NO. 1704740-52-2] AZ PFKFB3 26
PRODUCTS SPECIFICATIONS [1704740-52-2]
DESCRIPTION [1704740-52-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 402.49 |
| Molecular Formula | C24H26N4O2 |
| SMILES | O=C([C@H]1NCCC1)NC2=CC=C(OC3=CC4=C(N(CC(C)C)C=C4C#N)C=C3)C=C2 |
1 Publications Citing Use of MCE
Summary
AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC 50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC 50 s of 2.06 and 0.384 μM, respectively [1] .
IC50 & Target
IC50: 23 nM (PFKFB3), 2.06 μM (PFKFB1), 0.384 μM (PFKFB2) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 5 mg/mL ( 12.42 mM ; ultrasonic and adjust pH to 3 with HCl)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4845 mL | 12.4227 mL | 24.8453 mL |
| 5 mM | 0.4969 mL | 2.4845 mL | 4.9691 mL |
| 10 mM | 0.2485 mL | 1.2423 mL | 2.4845 mL |
