[CAS NO. 17360-35-9] Oxotremorine sesquifumarate

Name: Oxotremorine sesquifumarate
Brand: Arctom Scientific
SKU: AS929988

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PRODUCTS SPECIFICATIONS [17360-35-9]

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Catalog

AS929988

Brand

Arctom Scientific

CAS

17360-35-9

DESCRIPTION [17360-35-9]

Overview

MDL	MFCD00013163
Molecular Weight	380.40
Molecular Formula	C16H22N2O5
SMILES	O=C1N(CC#CCN2CCCC2)CCC1.O=C(O)/C=C/C(O)=O.[3/2]

For research use only. We do not sell to patients.

Summary

Oxotremorine sesquifumarate is a mAChR agonist that mainly activates M2 receptors. Oxotremorine sesquifumarate can be used for neurological research ^[1] ^[2] .

In Vitro

Oxotremorine (10.5 μM) produces a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rats with sciatic nerve injuries, Oxotremorine (10, 5, 2 1 μg; 10 μL) i.t. dose-dependently suppresses the tactile hypersensitivity ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 328.60 mM ; Need ultrasonic)

H ₂ O : 100 mg/mL ( 262.88 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6288 mL	13.1441 mL	26.2881 mL
5 mM	0.5258 mL	2.6288 mL	5.2576 mL
10 mM	0.2629 mL	1.3144 mL	2.6288 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-, (2E)-2-butenedioate (2:3)

2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butynyl]-, fumarate (2:3)

2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butynyl]-, (E)-2-butenedioate (2:3)

2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butynyl]-, (2E)-2-butenedioate (2:3)

Oxotremorine sesquifumarate

Oxotremorine fumarate (2:3)