[CAS NO. 175013-84-0] Tonabersat

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PRODUCTS SPECIFICATIONS [175013-84-0]

Catalog

HY-15204

Brand

MCE

CAS

175013-84-0

DESCRIPTION [175013-84-0]

Overview

MDL	MFCD00944458
Molecular Weight	391.82
Molecular Formula	C20H19ClFNO4
SMILES	O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O

For research use only. We do not sell to patients.

11 Publications Citing Use of MCE

Summary

Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system ^[1] ^[2] ^[3] .

IC50 & Target

Gap-junction ^[1]

In Vitro

Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment with Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00332007	Minster Research Ltd\|University of Copenhagen	Migraine With Aura	May 2006	Phase 2
NCT00534560	Minster Research Ltd	Migraine Without Aura\|Migraine With Aura	October 2007	Phase 2
NCT00311662	Minster Research Ltd	Migraine Without Aura\|Migraine With Aura	April 2006	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 255.22 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5522 mL	12.7610 mL	25.5219 mL
5 mM	0.5104 mL	2.5522 mL	5.1044 mL
10 mM	0.2552 mL	1.2761 mL	2.5522 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (6.38 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution
4.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 2.5 mg/mL (6.38 mM); Suspended solution

* All of the co-solvents are available by MCE.