[CAS NO. 17720-18-2] Nicotinic acid riboside
PRODUCTS SPECIFICATIONS [17720-18-2]
DESCRIPTION [17720-18-2]
Overview
| MDL | MFCD30730071 |
|---|---|
| Molecular Weight | 255.22 |
| Molecular Formula | C11H13NO6 |
| SMILES | [O-]C(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O |
Summary
In Vitro
Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations
[1]
.
.
Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 62.5 mg/mL ( 244.89 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9182 mL | 19.5909 mL | 39.1819 mL |
| 5 mM | 0.7836 mL | 3.9182 mL | 7.8364 mL |
| 10 mM | 0.3918 mL | 1.9591 mL | 3.9182 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (391.82 mM); Clear solution; Need ultrasonic
References
- [1] Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842.
- [2] Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [
Synonyms
