[CAS NO. 177931-17-8] Sauchinone

Name: Sauchinone
Brand: Arctom Scientific
SKU: AS256527

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PRODUCTS SPECIFICATIONS [177931-17-8]

Distributor

Catalog

AS256527

Brand

Arctom Scientific

CAS

177931-17-8

DESCRIPTION [177931-17-8]

Overview

MDL	MFCD08702698
Molecular Weight	356.37
Molecular Formula	C20H20O6
SMILES	C[C@@H]([C@@H](C[C@]12[H])C)[C@](C(C=C(OCO3)C3=C4)=C4O5)([H])[C@@]1([H])[C@]5(OCO6)C6=CC2=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Nat Med. 2020 Sep;74(4):777-787.

Summary

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS , TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity ^[1] .

IC50 & Target

I-kappaBalpha

p65

In Vitro

Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells ^[1] .
Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 22.73 mg/mL ( 63.78 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8061 mL	14.0304 mL	28.0607 mL
5 mM	0.5612 mL	2.8061 mL	5.6121 mL
10 mM	0.2806 mL	1.4030 mL	2.8061 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.27 mg/mL (6.37 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.27 mg/mL (6.37 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Lee AK, et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 2003 May;139(1):11-20.

Synonyms

5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)-

5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aα,7α,8β,8aβ,14aS*,14bβ)-

(5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one

Sauchinone