[CAS NO. 179411-93-9] SDZ220-581hydrochloride
PRODUCTS SPECIFICATIONS [179411-93-9]
DESCRIPTION [179411-93-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 406.20 |
| Molecular Formula | C16H18Cl2NO5P |
| SMILES | ClC1=CC=CC=C1C2=CC(C[C@H](N)C(O)=O)=CC(CP(O)(O)=O)=C2.[H]Cl |
Summary
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pK i value of 7.7 [1] .
IC50 & Target
pKi: 7.7 ( NMDA receptor ) [1]
In Vivo
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male OF-l mice (18-26 g) [1] |
| Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
| Administration: | Oral administration; for 24 hours |
| Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5 mg/mL ( 12.31 mM ; Need ultrasonic and warming)
H 2 O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4618 mL | 12.3092 mL | 24.6184 mL |
| 5 mM | 0.4924 mL | 2.4618 mL | 4.9237 mL |
| 10 mM | 0.2462 mL | 1.2309 mL | 2.4618 mL |
References
- [1] Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):655-69.
- [2] Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.
Synonyms
