[CAS NO. 179528-45-1] PD150606
PRODUCTS SPECIFICATIONS [179528-45-1]
DESCRIPTION [179528-45-1]
Overview
| MDL | MFCD00949076 |
|---|---|
| Molecular Weight | 306.12 |
| Molecular Formula | C9H7IO2S |
| SMILES | O=C(O)/C(S)=C/C1=CC=C(I)C=C1 |
4 Publications Citing Use of MCE
Summary
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective [1] .
IC50 & Target
Ki: 0.21 μM (μ-calpains), 0.37 μM (m-calpains) [1]
In Vitro
PD150606 interacts with both calcium-binding domains (μ- and m-calpains) of Calpain
[1]
.
PD150606 attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices
[1]
.
PD 150606 (25 μM; 0-12 hours) reduces Cycloheximide (10 mg/ml) -triggered apoptosis of neutrophils
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 28 mg/mL ( 91.47 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2667 mL | 16.3335 mL | 32.6669 mL |
| 5 mM | 0.6533 mL | 3.2667 mL | 6.5334 mL |
| 10 mM | 0.3267 mL | 1.6333 mL | 3.2667 mL |
References
- [1] 1. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
- [2] 2. Squier MK , et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9.
Synonyms
