[CAS NO. 1799711-25-3] Thalidomide-O-amido-C4-NH2 TFA

Name: Thalidomide-O-amido-C4-NH2 TFA
Brand: Arctom Scientific
SKU: AS947264

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PRODUCTS SPECIFICATIONS [1799711-25-3]

Distributor

Catalog

AS947264

Brand

Arctom Scientific

CAS

1799711-25-3

DESCRIPTION [1799711-25-3]

Overview

MDL	-
Molecular Weight	516.42
Molecular Formula	C21H23F3N4O8
SMILES	NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.FC(F)(F)C(O)=O

For research use only. We do not sell to patients.

Summary

Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC50 & Target

Cereblon

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 42.86 mg/mL ( 82.99 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9364 mL	9.6820 mL	19.3641 mL
5 mM	0.3873 mL	1.9364 mL	3.8728 mL
10 mM	0.1936 mL	0.9682 mL	1.9364 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

* All of the co-solvents are available by MCE.