[CAS NO. 1821370-70-0] Diethyl-pythiDC
PRODUCTS SPECIFICATIONS [1821370-70-0]
DESCRIPTION [1821370-70-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 306.34 |
| Molecular Formula | C14H14N2O4S |
| SMILES | O=C(C1=CC=C(C2=NC=C(C(OCC)=O)S2)N=C1)OCC |
1 Publications Citing Use of MCE
Summary
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).
IC50 & Target
CP4H [1]
In Vitro
Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. MDA-MB-231 cells are treated with biheteroaryl dicarboxylates, and assayed for cytotoxicity and indicators of iron deficiency. None of the esterified biheteroaryl dicarboxylates exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate (EDHB demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC (Diethyl pythiDC) appear to be normal at concentrations as high as 500 µM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 108.80 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2643 mL | 16.3217 mL | 32.6435 mL |
| 5 mM | 0.6529 mL | 3.2643 mL | 6.5287 mL |
| 10 mM | 0.3264 mL | 1.6322 mL | 3.2643 mL |
