[CAS NO. 1835705-57-1] (S,R,S)-AHPC-PEG2-C4-Cl
PRODUCTS SPECIFICATIONS [1835705-57-1]
DESCRIPTION [1835705-57-1]
Overview
| MDL | MFCD31560480 |
|---|---|
| Molecular Weight | 651.26 |
| Molecular Formula | C32H47ClN4O6S |
| SMILES | O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2 |
Summary
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays [1] .
IC50 & Target
|
VHL |
In Vitro
(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand [1] . The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 76.77 mM )
Ethanol : 50 mg/mL ( 76.77 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5355 mL | 7.6774 mL | 15.3548 mL |
| 5 mM | 0.3071 mL | 1.5355 mL | 3.0710 mL |
| 10 mM | 0.1535 mL | 0.7677 mL | 1.5355 mL |
References
