[CAS NO. 1835705-59-3] (S,R,S)-AHPC-PEG6-C4-Cl
PRODUCTS SPECIFICATIONS [1835705-59-3]
DESCRIPTION [1835705-59-3]
Overview
| MDL | MFCD31560479 |
|---|---|
| Molecular Weight | 827.47 |
| Molecular Formula | C40H63ClN4O10S |
| SMILES | O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2 |
Summary
(S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays [1] .
IC50 & Target
|
VHL |
In Vitro
HaloPROTACs are designed to induce ubiquitylation and degradation of HaloTag7 fusion proteins [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : 100 mg/mL ( 120.85 mM ; Need ultrasonic)
DMSO : ≥ 100 mg/mL ( 120.85 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.2085 mL | 6.0425 mL | 12.0850 mL |
| 5 mM | 0.2417 mL | 1.2085 mL | 2.4170 mL |
| 10 mM | 0.1209 mL | 0.6043 mL | 1.2085 mL |
Synonyms
