[CAS NO. 1883602-20-7] TES-991
PRODUCTS SPECIFICATIONS [1883602-20-7]
DESCRIPTION [1883602-20-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 393.45 |
| Molecular Formula | C17H11N7OS2 |
| SMILES | N#CC1=C(C2=CC=CS2)NC(SCC3=CC=CC(C4=NN=NN4)=C3)=NC1=O |
1 Publications Citing Use of MCE
Summary
TES-991 is a potent and selective human α‑Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC 50 of 3 nM.
IC50 & Target
IC50: 3 nM (hACMSD) [1] .
In Vitro
TES-991 (compounds 21) is able to significantly increase intracellular NAD + levels, providing further proof of their mechanism of action. TES-991 shows an inhibition of cytochrome P450 2C19, suggesting a possible involvement of the 2H-tetrazole motif in this interaction [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After the intravenous administration of 0.5 mg/kg, TES-991 (compound 21) shows low blood clearance, with low volumes of distribution and halflives (t 1/2 ) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 158.85 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5416 mL | 12.7081 mL | 25.4162 mL |
| 5 mM | 0.5083 mL | 2.5416 mL | 5.0832 mL |
| 10 mM | 0.2542 mL | 1.2708 mL | 2.5416 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.29 mM); Clear solution
