[CAS NO. 1884222-74-5] SBP-7455
PRODUCTS SPECIFICATIONS [1884222-74-5]
DESCRIPTION [1884222-74-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 354.33 |
| Molecular Formula | C16H17F3N4O2 |
| SMILES | FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F |
Summary
IC50 & Target
|
ULK1 13 nM (IC 50 ) |
ULK2 476 nM (IC 50 ) |
In Vitro
SBP-7455 (compound 26; 72 h) treatment inhibits cell growth with an IC 50 of 0.3 μM for MDA-MB-468 cells. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells that are dependent on autophagy for survival [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
A single dose of SBP-7455 (compound 26) (30 mg/kg) is orally administered to mice. The T
max
for SBP-7455 is approximately 1 h, the C
max
is 990 nM and the T
1/2
is 1.7 h. The plasma concentration of SBP-7455 remains above the ULK1 IC
50
for almost 4 h after oral dosing
[1]
.
The mice are dosed with SBP-7455 (compound 26) (10 mg/kg) by oral gavage, and liver samples were collected after 2 h. The results reveals robust inhibition of pATG13 (Ser318), as well as downregulation of total ATG13 and ULK1 levels by SBP-7455
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 352.78 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8222 mL | 14.1111 mL | 28.2223 mL |
| 5 mM | 0.5644 mL | 2.8222 mL | 5.6445 mL |
| 10 mM | 0.2822 mL | 1.4111 mL | 2.8222 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution
