[CAS NO. 192203-60-4] CarboxypeptidaseG2(CPG2)Inhibitor
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PRODUCTS SPECIFICATIONS [192203-60-4]
Distributor
Catalog
AS251804
Brand
Arctom Scientific
CAS
192203-60-4
DESCRIPTION [192203-60-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 313.33 |
| Molecular Formula | C13H15NO6S |
| SMILES | O=C(SC(C=C1)=CC=C1OC)N[C@@H](CCC(O)=O)C(O)=O |
For research use only. We do not sell to patients.
Summary
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
In Vitro:
H 2 O : 1.43 mg/mL ( 4.56 mM ; Need ultrasonic)
Preparing
Stock Solutions
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1915 mL | 15.9576 mL | 31.9152 mL |
| 5 mM | --- | --- | --- |
| 10 mM | --- | --- | --- |
*
Please refer to the solubility information to select the appropriate solvent.
References
- [1] Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.
- [2] Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.
- [3] Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.
- [4] Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.
Synonyms
L-Glutamic acid, N-[[(4-methoxyphenyl)thio]carbonyl]-
N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid
(S)-2-((((4-Methoxyphenyl)thio)carbonyl)amino)pentanedioic acid
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