[CAS NO. 194920-62-2]  N-Boc-C1-PEG3-C3-NH2

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PRODUCTS SPECIFICATIONS [194920-62-2]

Fulfillment
Catalog
AS502027
Brand
Arctom Scientific
CAS
194920-62-2

DESCRIPTION [194920-62-2]

Overview

MDLMFCD04973133
Molecular Weight320.42
Molecular FormulaC15H32N2O5
SMILESO=C(OC(C)(C)C)NCCCOCCOCCOCCCN

For research use only. We do not sell to patients.

Summary

N-Boc-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 312.09 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1209 mL 15.6045 mL 31.2090 mL
5 mM 0.6242 mL 3.1209 mL 6.2418 mL
10 mM 0.3121 mL 1.5605 mL 3.1209 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

* All of the co-solvents are available by MCE.