[CAS NO. 1950635-14-9] Thalidomide-O-amido-C6-NH2TFA

Name: Thalidomide-O-amido-C6-NH2TFA
Brand: Arctom Scientific
SKU: AS945086

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PRODUCTS SPECIFICATIONS [1950635-14-9]

Distributor

Catalog

AS945086

Brand

Arctom Scientific

CAS

1950635-14-9

DESCRIPTION [1950635-14-9]

Overview

MDL	MFCD31715439
Molecular Weight	544.48
Molecular Formula	C23H27F3N4O8
SMILES	O=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F

For research use only. We do not sell to patients.

Summary

Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 183.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8366 mL	9.1831 mL	18.3661 mL
5 mM	0.3673 mL	1.8366 mL	3.6732 mL
10 mM	0.1837 mL	0.9183 mL	1.8366 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1