[CAS NO. 1957236-21-3] Thalidomide-O-amido-PEG3-C2-NH2 TFA

Name: Thalidomide-O-amido-PEG3-C2-NH2 TFA
Brand: Arctom Scientific
SKU: AS947263

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PRODUCTS SPECIFICATIONS [1957236-21-3]

Fulfillment

Catalog

AS947263

Brand

Arctom Scientific

CAS

1957236-21-3

DESCRIPTION [1957236-21-3]

Overview

MDL	-
Molecular Weight	620.53
Molecular Formula	C25H31F3N4O11
SMILES	O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCOCCOCCOCCN)=O.FC(F)(F)C(O)=O

For research use only. We do not sell to patients.

Summary

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 80.58 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6115 mL	8.0576 mL	16.1153 mL
5 mM	0.3223 mL	1.6115 mL	3.2231 mL
10 mM	0.1612 mL	0.8058 mL	1.6115 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] BRADNER, James, et al. METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES. WO2017024317A2.

Synonyms

Acetamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 2,2,2-trifluoroacetate (1:1)