[CAS NO. 19767-45-4] Sodium2-mercaptoethanesulfonate
PRODUCTS SPECIFICATIONS [19767-45-4]
DESCRIPTION [19767-45-4]
Overview
| MDL | MFCD00007535 |
|---|---|
| Molecular Weight | 164.18 |
| Molecular Formula | C2H5NaO3S2 |
| SMILES | SCCS(=O)(O[Na])=O |
1 Publications Citing Use of MCE
Summary
In Vitro
Mesna (1-1000 μM) reduces H 2 O 2 , HOCl and OH• concentrations in a dose-dependent manner, with an IC 50 of 32, 21, and 305 μM, respectively in cell-free experiments [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury
[1]
.
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI) [1] |
| Dosage: | 150 mg/kg |
| Administration: | A single i.p. |
| Result: |
Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase. Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase. Protected the brain tissues well from injury. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : ≥ 50 mg/mL ( 304.54 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.0909 mL | 30.4544 mL | 60.9088 mL |
| 5 mM | 1.2182 mL | 6.0909 mL | 12.1818 mL |
| 10 mM | 0.6091 mL | 3.0454 mL | 6.0909 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (609.09 mM); Clear solution; Need ultrasonic
References
- [1] Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149.
- [2] Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85.
- [3] Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17(3):76-80.
Synonyms
