[CAS NO. 199331-35-6] Dehydroglyasperin C
PRODUCTS SPECIFICATIONS [199331-35-6]
DESCRIPTION [199331-35-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 354.40 |
| Molecular Formula | C21H22O5 |
| SMILES | OC1=CC=C(C2=CC3=C(OC)C(C/C=C(C)\C)=C(O)C=C3OC2)C(O)=C1 |
Summary
In Vitro
Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF
[1]
.
Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cycle Analysis [1]
| Cell Line: | Human aortic smooth muscle cells (HASMC) |
| Concentration: | 0.1 μM, 0.5 μM, 1 μM |
| Incubation Time: | 24 hours |
| Result: | Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle. |
Western Blot Analysis [1]
| Cell Line: | Human aortic smooth muscle cells (HASMC) |
| Concentration: | 0.1 μM, 0.5 μM, 1 μM |
| Incubation Time: | 24 hours |
| Result: | Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. |
In Vivo
In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Hyo Jung Kim, et al. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. Br J Nutr. 2013 Aug 28;110(3):391-400.
- [2] Ji Hoon Lee, et al. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Mol Carcinog. 2016 May;55(5):552-62.
- [3] Ji Yeon Seo, et al. Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes. J Agric Food Chem. 2010 Feb 10;58(3):1603-8.
- [4] Seo, J.Y, et al. Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice. Food Sci Biotechnol 23, 547–553 (2014).
