[CAS NO. 1996629-79-8] TBOPP
PRODUCTS SPECIFICATIONS [1996629-79-8]
DESCRIPTION [1996629-79-8]
Overview
| MDL | MFCD32215320 |
|---|---|
| Molecular Weight | 490.49 |
| Molecular Formula | C24H21F3N2O4S |
| SMILES | O=C1C=CC(S(=O)(N2CCCC2)=O)=CN1CC(C3=CC=C(C4=CC=CC(C(F)(F)F)=C4)C=C3)=O |
Summary
TBOPP is a selective inhibitor of DOCK1 with an IC 50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with high affinity ( K d of 7.1 μM), has anti-tumor activity for broader types of tumors [1] .
IC50 & Target
IC50: 8.4 μM (DOCK1); Kd: 7.1 μM (DOCK1 DHR-2 domain) [1]
In Vitro
TBOPP (12.5 µM; 3 days; 3LL cells) treatment inhibits DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | 3LL cells |
| Concentration: | 12.5 µM |
| Incubation Time: | 3 days |
| Result: | Inhibited cell viability. |
In Vivo
TBOPP (0.67 mg per mouse; administrated on days 0, 1, 3, and 5; for 2 weeks; C57BL/6 mice) treatment effectively suppresses metastasis of cancer cells in vivo and the number of lymphocytes in the spleen is not changed, the body weight is also unchanged between TBOPP-treated and non-treated mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6 mice (6- to 8-week-old) with ex-3LL cells [1] |
| Dosage: | 0.67 mg per mouse |
| Administration: | Administrated on days 0, 1, 3, and 5; for 2 weeks |
| Result: | The lung metastasis was significantly suppressed. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 203.88 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0388 mL | 10.1939 mL | 20.3878 mL |
| 5 mM | 0.4078 mL | 2.0388 mL | 4.0776 mL |
| 10 mM | 0.2039 mL | 1.0194 mL | 2.0388 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution
